You've most probably experienced this before if you're 'gamer'
enough to have discovered Spelunky. It almost always happens when switching windows (with Alt-Tab, et cetera) while playing flash games, to cite a popular example of where this happens.
All you have to do is to press each one of these keys once
. Still, I've had no experience with a wireless 'remote', so who knows? But it probably will fix your problem.